Delphinine

Delphinine
Names
Other names
8-(Acetyloxy)-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-20-methylaconitan-14-yl benzoate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.008.377 Edit this at Wikidata
UNII
  • InChI=1S/C33H45NO9/c1-18(35)43-32-15-22(40-5)31(37)14-20(23(32)28(31)42-29(36)19-10-8-7-9-11-19)33-21(39-4)12-13-30(17-38-3)16-34(2)27(33)24(32)25(41-6)26(30)33/h7-11,20-28,37H,12-17H2,1-6H3/t20-,21+,22+,23-,24+,25+,26-,27?,28-,30+,31+,32-,33+/m1/s1 checkY
    Key: REVYTWNGZDPRKE-UWZYQZSNSA-N checkY
  • InChI=1/C33H45NO9/c1-18(35)43-32-15-22(40-5)31(37)14-20(23(32)28(31)42-29(36)19-10-8-7-9-11-19)33-21(39-4)12-13-30(17-38-3)16-34(2)27(33)24(32)25(41-6)26(30)33/h7-11,20-28,37H,12-17H2,1-6H3/t20-,21+,22+,23-,24+,25+,26-,27?,28-,30+,31+,32-,33+/m1/s1
    Key: REVYTWNGZDPRKE-UWZYQZSNBH
  • CC(=O)O[C@]12C[C@@H]([C@]3(C[C@H]([C@@H]1[C@H]3OC(=O)C4=CC=CC=C4)[C@]56[C@H](CC[C@@]7([C@H]5[C@H]([C@H]2C6N(C7)C)OC)COC)OC)O)OC
  • O=C(O[C@H]5[C@]3(O)C[C@H]4[C@@]16C2N(C)C[C@]([C@H]1[C@@H](OC)[C@@H]2[C@@](OC(=O)C)(C[C@@H]3OC)[C@H]45)(COC)CC[C@@H]6OC)c7ccccc7
Properties
C33H45NO9
Molar mass 599.712
Appearance colorless solid
Melting point 197 to 199 °C (387 to 390 °F; 470 to 472 K)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Delphinine is a toxic diterpenoid alkaloid found in plants from the Delphinium (larkspur) and Atragene (a clematis) genera, both in the family Ranunculaceae. Delphinine is the principal alkaloid found in Delphinium staphisagria seeds – at one time, under the name stavesacre, a very well known herbal treatment for body lice. It is related in structure and has similar effects to aconitine, acting as an allosteric modulator of voltage gated sodium channels, and producing low blood pressure, slowed heart rate and abnormal heart rhythms. These effects make it highly poisonous (LD50 1.5–3.0 mg/kg in rabbit and dog; frogs are ~10x more susceptible). While it has been used in some alternative medicines (e.g. in herbal medicine), most of the medical community does not recommend using it due to its extreme toxicity.

Isolation

One of the earliest reports of the isolation of delphinine, from D. staphisagria, was that of the French chemists Lassaigne and Feneulle, in 1819. A less antique and more accessible report is that of the USDA chemist L. N. Markwood, who also briefly reviewed the earlier isolation work. Notably, these early isolations were carried out without the aid of chromatography, since delphinine crystallizes readily from a petroleum ether extract after the typical acid-base cycling used in traditional plant alkaloid-extraction methods.

Chemistry

Despite the relative ease of isolation and early discovery of delphinine, its molecular structure was not established in its currently accepted form until the early 1970s. At that time, Wiesner's research group corrected the stereochemistry of the methoxy group at C-1 from the β- to the α- configuration. Thus, any drawing of the delphinine molecule appearing before 1971–1972 is likely to show the incorrect stereochemistry at C-1.

Pharmacology

As a result of its early discovery and isolation in crystalline form (then considered a criterion of purity), the pharmacological properties of delphinine were extensively investigated in the 19th Century, despite the fact that its molecular structure was unknown. It is likely that some of these investigations were carried out with impure drug and should be interpreted with caution. References to and commentary on these early studies may be found in the review by Benn and Jacyno. More recent studies focused on the cardiovascular toxicity of delphinine.

In general, the pharmacology of delphinine seems to resemble that of aconitine, although the acute toxicity of delphinine appears to be lower than that of aconitine in test animals.


This page was last updated at 2024-01-27 18:02 UTC. Update now. View original page.

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