Farletuzumab

Farletuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetFR-alpha
Clinical data
Routes of
administration
Intravenous injection
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6466H9928N1716O2020S42
Molar mass145371.06 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Farletuzumab (MORAb-003) is a humanized monoclonal antibody of IgG1/κ which is being investigated for the treatment of ovarian cancer.

This drug was developed by Morphotek, Inc.

It is targeted at folate receptor alpha (FRα) which is overexpressed in some cancers such as epithelial ovarian cancer (EOC) and non-small-cell lung carcinoma.

Mechanism of action

Farletuzumab uses the following mechanisms of action:

  • Antibody-dependent cellular cytotoxicity
  • Complement-dependent cytotoxicity
  • Inhibition of interaction between FRα and Lyn kinase
  • Induces cell death associated with autophagy

Adverse effects

Common adverse effects include hypersensitivity reactions, fever, chills, headache, fatigue, and diarrhea.


This page was last updated at 2023-11-24 03:34 UTC. Update now. View original page.

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