HDAC1
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.
Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Interactions
HDAC1 has been shown to interact with:
- Androgen receptor,
- BCL6,
- BTG2,
- BUB1B,
- BUB1,
- BUB3,
- CBFA2T3,
- CDC20,
- CDH1,
- CHD3,
- CHD4,
- COUP-TFII,
- CTBP1,
- DDX17,
- DDX5,
- DNMT3A,
- DNMT3L,
- Death-associated protein 6,
- EED,
- EVI1,
- EZH2,
- FKBP3,
- GATA1,
- HMG20B,
- HSPA4,
- HUS1,
- Histone deacetylase 2,
- Homeobox protein TGIF1,
- Host cell factor C1,
- IFRD1,
- IKZF1,
- ING1,
- MBD3,
- MIER1,
- MLL,
- MTA1,
- MTA2,
- Mad1,
- Mdm2,
- Methyl-CpG-binding domain protein 2,
- Mothers against decapentaplegic homolog 2,
- MyoD,
- NFKB1,
- Nuclear receptor co-repressor 2,
- P21,
- PCNA,
- PHF21A,
- Prohibitin,
- Promyelocytic leukemia protein,
- RAD9A,
- RBBP4,
- RBBP7,
- RCOR1,
- RELA,
- RFC1,
- Retinoblastoma protein,
- Retinoblastoma-like protein 1,
- Retinoblastoma-like protein 2,
- SAP30,
- SATB1,
- SIN3A,
- SIN3B,
- SPEN,
- SUDS3,
- SUV39H1,
- Sp1 transcription factor,
- TOP2A,
- TOP2B, and
- Zinc finger and BTB domain-containing protein 16.