HDAC1

HDAC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
External IDsOMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004964

NM_008228

RefSeq (protein)

NP_004955

NP_032254

Location (UCSC)Chr 1: 32.29 – 32.33 MbChr 4: 129.41 – 129.44 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Interactions

HDAC1 has been shown to interact with:

See also


This page was last updated at 2024-02-11 13:53 UTC. Update now. View original page.

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