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Julian Parkhill

Julian Parkhill
Dr Julian Parkhill FMedSci FRS.jpg
Julian Parkhill in 2015
Julian Parkhill

(1964-09-23) 23 September 1964 (age 55)[1]
Alma mater
Known forARTEMIS[2][3][4]
Scientific career
ThesisRegulation of transcription of the mercury resistance operon of Tn501 (1991)

Julian Parkhill (born 1964)[1] FRS[7] is a Professor in the Department of Veterinary Medicine[11] at the University of Cambridge. He was previously head of Pathogen Genomics at the Wellcome Trust Sanger Institute.[12][13][14][15][8][16][17]


Parkhill was educated at Westcliff High School for Boys,[1] the University of Birmingham and the University of Bristol where he was awarded a PhD in 1991[18] for research into the regulation of transcription of the mercury resistance operon.[9][10][19]


Parkhill uses high throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host–pathogen interaction.[20][21][22][23][24][25][26][27][28][29][30][31][32] Research in the Parkill Laboratory has been funded the Wellcome Trust, the Biotechnology and Biological Sciences Research Council (BBSRC)[33] and the Medical Research Council (MRC).[34]

Awards and honours

Parkhill was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2009,[5] and a Fellow of the American Academy of Microbiology (FAAM) in 2012.

Parkhill was elected a Fellow of the Royal Society (FRS) in 2014,[7] his certificate of election reads:


  1. ^ a b c d "PARKHILL, Dr Julian". Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription or UK public library membership required) (subscription required)
  2. ^ Rutherford, K.; Parkhill, J.; Crook, J.; Horsnell, T.; Rice, P.; Rajandream, M.-A.; Barrell, B. (2000). "Artemis: Sequence visualization and annotation". Bioinformatics. 16 (10): 944–5. doi:10.1093/bioinformatics/16.10.944. PMID 11120685.
  3. ^ Carver, T; Berriman, M; Tivey, A; Patel, C; Böhme, U; Barrell, B. G.; Parkhill, J; Rajandream, M. A. (2008). "Artemis and ACT: Viewing, annotating and comparing sequences stored in a relational database". Bioinformatics. 24 (23): 2672–6. doi:10.1093/bioinformatics/btn529. PMC 2606163. PMID 18845581.
  4. ^ Carver, T.; Harris, S. R.; Berriman, M.; Parkhill, J.; McQuillan, J. A. (2011). "Artemis: An integrated platform for visualization and analysis of high-throughput sequence-based experimental data". Bioinformatics. 28 (4): 464–469. doi:10.1093/bioinformatics/btr703. PMC 3278759. PMID 22199388.
  5. ^ a b "Fellow | Academy of Medical Sciences". Retrieved 18 November 2016.
  6. ^ a b "Julian Parkhill". Retrieved 18 November 2016.
  7. ^ a b c d Anon (2014). "Professor Julian Parkhill FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.CS1 maint: BOT: original-url status unknown (link)

  8. ^ a b Julian Parkhill publications indexed by Google Scholar Edit this at Wikidata
  9. ^ a b Parkhill, J; Brown, N. L. (1990). "Site-specific insertion and deletion mutants in the mer promoter-operator region of Tn501; the nineteen base-pair spacer is essential for normal induction of the promoter by MerR". Nucleic Acids Research. 18 (17): 5157–62. doi:10.1093/nar/18.17.5157. PMC 332137. PMID 2169606.
  10. ^ a b Brown, N. L.; Camakaris, J; Lee, B. T.; Williams, T; Morby, A. P.; Parkhill, J; Rouch, D. A. (1991). "Bacterial resistances to mercury and copper". Journal of Cellular Biochemistry. 46 (2): 106–14. doi:10.1002/jcb.240460204. PMID 1717500.
  11. ^ "Professor Julian Parkhill — Research in the Department of Veterinary Medicine". Retrieved 7 August 2019.
  12. ^ "Professor Julian Parkhill, FRS, FMedSci, Senior Group Leader". Archived from the original on 15 March 2016.
  13. ^ Parkhill, J. (2013). "What has high-throughput sequencing ever done for us?". Nature Reviews Microbiology. 11 (10): 664–5. doi:10.1038/nrmicro3112. PMID 23979431.
  14. ^ List of publications from Microsoft Academic
  15. ^ Julian Parkhill at DBLP Bibliography Server Edit this at Wikidata
  16. ^ Julian Parkhill's publications indexed by the Scopus bibliographic database. (subscription required)
  17. ^ Professor Julian Parkhill visits the Wellcome Collection in London to unravel the Science behind the genome on YouTube
  18. ^ Parkhill, Julian (1991). Regulation of transcription of the mercury resistance operon of Tn501 (PhD thesis). University of Bristol. OCLC 931563576. ProQuest 301408708.(subscription required)
  19. ^ Holden, M. T. G.; Feil, E.; Lindsay, J.; Peacock, S.; Day, N.; Enright, M.; Foster, T.; Moore, C.; Hurst, L.; Atkin, R.; Barron, A.; Bason, N.; Bentley, S. D.; Chillingworth, C.; Chillingworth, T.; Churcher, C.; Clark, L.; Corton, C.; Cronin, A.; Doggett, J.; Dowd, L.; Feltwell, T.; Hance, Z.; Harris, B.; Hauser, H.; Holroyd, S.; Jagels, K.; James, K. D.; Lennard, N.; Line, A. (2004). "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance". Proceedings of the National Academy of Sciences. 101 (26): 9786–9791. doi:10.1073/pnas.0402521101. PMC 470752. PMID 15213324. open access
  20. ^ Parkhill, J; Birney, E; Kersey, P (2010). "Genomic information infrastructure after the deluge". Genome Biology. 11 (7): 402. doi:10.1186/gb-2010-11-7-402. PMC 2926780. PMID 20670392.
  21. ^ Cole, S. T.; Brosch, R.; Parkhill, J.; Garnier, T.; Churcher, C.; Harris, D.; Gordon, S. V.; Eiglmeier, K.; Gas, S.; Barry, C. E.; Tekaia, F.; Badcock, K.; Basham, D.; Brown, D.; Chillingworth, T.; Connor, R.; Davies, R.; Devlin, K.; Feltwell, T.; Gentles, S.; Hamlin, N.; Holroyd, S.; Hornsby, T.; Jagels, K.; Krogh, A.; McLean, J.; Moule, S.; Murphy, L.; Oliver, K.; et al. (1998). "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence". Nature. 393 (6685): 537–44. doi:10.1038/31159. PMID 9634230.
  22. ^ Bentley, S. D.; Chater, K. F.; Cerdeño-Tárraga, A. -M.; Challis, G. L.; Thomson, N. R.; James, K. D.; Harris, D. E.; Quail, M. A.; Kieser, H.; Harper, D.; Bateman, A.; Brown, S.; Chandra, G.; Chen, C. W.; Collins, M.; Cronin, A.; Fraser, A.; Goble, A.; Hidalgo, J.; Hornsby, T.; Howarth, S.; Huang, C. -H.; Kieser, T.; Larke, L.; Murphy, L.; Oliver, K.; O'Neil, S.; Rabbinowitsch, E.; Rajandream, M. -A.; et al. (2002). "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)". Nature. 417 (6885): 141–7. doi:10.1038/417141a. PMID 12000953.
  23. ^ Qin, J.; Li, R.; Raes, J.; Arumugam, M.; Burgdorf, K. S.; Manichanh, C.; Nielsen, T.; Pons, N.; Levenez, F.; Yamada, T.; Mende, D. R.; Li, J.; Xu, J.; Li, S.; Li, D.; Cao, J.; Wang, B.; Liang, H.; Zheng, H.; Xie, Y.; Tap, J.; Lepage, P.; Bertalan, M.; Batto, J. M.; Hansen, T.; Le Paslier, D.; Linneberg, A.; Nielsen, H. B. R.; Pelletier, E.; Renault, P. (2010). "A human gut microbial gene catalogue established by metagenomic sequencing". Nature. 464 (7285): 59–65. doi:10.1038/nature08821. PMC 3779803. PMID 20203603.
  24. ^ Parkhill, J.; Wren, B. W.; Mungall, K.; Ketley, J. M.; Churcher, C.; Basham, D.; Chillingworth, T.; Davies, R. M.; Feltwell, T.; Holroyd, S.; Jagels, K.; Karlyshev, A. V.; Moule, S.; Pallen, M. J.; Penn, C. W.; Quail, M. A.; Rajandream, M. A.; Rutherford, K. M.; Van Vliet, A. H. M.; Whitehead, S.; Barrell, B. G. (2000). "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences". Nature. 403 (6770): 665–8. doi:10.1038/35001088. PMID 10688204.
  25. ^ Cole, S. T.; Eiglmeier, K.; Parkhill, J.; James, K. D.; Thomson, N. R.; Wheeler, P. R.; Honoré, N.; Garnier, T.; Churcher, C.; Harris, D.; Mungall, K.; Basham, D.; Brown, D.; Chillingworth, T.; Connor, R.; Davies, R. M.; Devlin, K.; Duthoy, S.; Feltwell, T.; Fraser, A.; Hamlin, N.; Holroyd, S.; Hornsby, T.; Jagels, K.; Lacroix, C.; MacLean, J.; Moule, S.; Murphy, L.; Oliver, K.; Quail, M. A. (2001). "Massive gene decay in the leprosy bacillus". Nature. 409 (6823): 1007–1011. doi:10.1038/35059006. PMID 11234002.
  26. ^ Parkhill, J.; Wren, B. W.; Thomson, N. R.; Titball, R. W.; Holden, M. T. G.; Prentice, M. B.; Sebaihia, M.; James, K. D.; Churcher, C.; Mungall, K. L.; Baker, S.; Basham, D.; Bentley, S. D.; Brooks, K.; Cerdeño-Tárraga, A. M.; Chillingworth, T.; Cronin, A.; Davies, R. M.; Davis, P.; Dougan, G.; Feltwell, T.; Hamlin, N.; Holroyd, S.; Jagels, K.; Karlyshev, A. V.; Leather, S.; Moule, S.; Oyston, P. C. F.; Quail, M.; et al. (2001). "Genome sequence of Yersinia pestis, the causative agent of plague". Nature. 413 (6855): 523–7. doi:10.1038/35097083. PMID 11586360.
  27. ^ Parkhill, J.; Dougan, G.; James, K. D.; Thomson, N. R.; Pickard, D.; Wain, J.; Churcher, C.; Mungall, K. L.; Bentley, S. D.; Holden, M. T. G.; Sebaihia, M.; Baker, S.; Basham, D.; Brooks, K.; Chillingworth, T.; Connerton, P.; Cronin, A.; Davis, P.; Davies, R. M.; Dowd, L.; White, N.; Farrar, J.; Feltwell, T.; Hamlin, N.; Haque, A.; Hien, T. T.; Holroyd, S.; Jagels, K.; Krogh, A.; et al. (2001). "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18". Nature. 413 (6858): 848–52. doi:10.1038/35101607. PMID 11677608.
  28. ^ Parkhill, J.; Achtman, M.; James, K. D.; Bentley, S. D.; Churcher, C.; Klee, S. R.; Morelli, G.; Basham, D.; Brown, D.; Chillingworth, T.; Davies, R. M.; Davis, P.; Devlin, K.; Feltwell, T.; Hamlin, N.; Holroyd, S.; Jagels, K.; Leather, S.; Moule, S.; Mungall, K.; Quail, M. A.; Rajandream, M. -A.; Rutherford, K. M.; Simmonds, M.; Skelton, J.; Whitehead, S.; Spratt, B. G.; Barrell, B. G. (2000). "Complete DNA sequence of a serogroup a strain of Neisseria meningitidis Z2491". Nature. 404 (6777): 502–6. doi:10.1038/35006655. PMID 10761919.
  29. ^ Parkhill, J.; Wren, B. W. (2011). "Bacterial epidemiology and biology - lessons from genome sequencing". Genome Biology. 12 (10): 230. doi:10.1186/gb-2011-12-10-230. PMC 3333767. PMID 22027015.
  30. ^ Garnier, T.; Eiglmeier, K.; Camus, J. -C.; Medina, N.; Mansoor, H.; Pryor, M.; Duthoy, S.; Grondin, S.; Lacroix, C.; Monsempe, C.; Simon, S.; Harris, B.; Atkin, R.; Doggett, J.; Mayes, R.; Keating, L.; Wheeler, P. R.; Parkhill, J.; Barrell, B. G.; Cole, S. T.; Gordon, S. V.; Hewinson, R. G. (2003). "The complete genome sequence of Mycobacterium bovis". Proceedings of the National Academy of Sciences. 100 (13): 7877–82. doi:10.1073/pnas.1130426100. PMC 164681. PMID 12788972.
  31. ^ Parkhill, J.; Sebaihia, M.; Preston, A.; Murphy, L. D.; Thomson, N.; Harris, D. E.; Holden, M. T. G.; Churcher, C. M.; Bentley, S. D.; Mungall, K. L.; Cerdeño-Tárraga, A. M.; Temple, L.; James, K.; Harris, B.; Quail, M. A.; Achtman, M.; Atkin, R.; Baker, S.; Basham, D.; Bason, N.; Cherevach, I.; Chillingworth, T.; Collins, M.; Cronin, A.; Davis, P.; Doggett, J.; Feltwell, T.; Goble, A.; Hamlin, N.; et al. (2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica". Nature Genetics. 35 (1): 32–40. doi:10.1038/ng1227. PMID 12910271.
  32. ^ Field, D.; Garrity, G.; Gray, T.; Morrison, N.; Selengut, J.; Sterk, P.; Tatusova, T.; Thomson, N.; Allen, M. J.; Angiuoli, S. V.; Ashburner, M.; Axelrod, N.; Baldauf, S.; Ballard, S.; Boore, J.; Cochrane, G.; Cole, J.; Dawyndt, P.; De Vos, P.; Depamphilis, C.; Edwards, R.; Faruque, N.; Feldman, R.; Gilbert, J.; Gilna, P.; Glöckner, F. O.; Goldstein, P.; Guralnick, R.; Haft, D.; et al. (2008). "The minimum information about a genome sequence (MIGS) specification". Nature Biotechnology. 26 (5): 541–7. doi:10.1038/nbt1360. PMC 2409278. PMID 18464787.
  33. ^ Anon (2014). "Grants awarded to Julian Parkhill by the BBSRC". BBSRC. Archived from the original on 4 March 2016.
  34. ^ Anon (2014). "UK Government grants awarded to Julian Parhill". Swindon: Research Councils UK. Archived from the original on 21 April 2015.

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