Zetekitoxin AB
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IUPAC name
[(3R,5S,6S,11R,12S,14Z,16S,17Z)-14,17-Diamino-19,19-dihydroxy-6-(hydroxymethyl)-10-oxo-3-(sulfooxy)-8-oxa-1,9,13,15,18-pentaazapentacyclo[9.5.2.1~3,16~.0~5,9~.0~12,16~]nonadeca-14,17-dien-13-yl]methyl hydroxycarbamate
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Other names
ZTX
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
PubChem CID
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Properties | |
C16H24N8O12S | |
Molar mass | 552.47 g·mol−1 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Extremely toxic |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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11 μg/kg (mice) |
Related compounds | |
Related compounds
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Saxitoxin Neosaxitoxin Tetrodotoxin |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Zetekitoxin AB (ZTX) is a guanidine alkaloid found in the Panamanian golden frog Atelopus zeteki. It is an extremely potent neurotoxin.
Structure
ZTX is a guanidine alkaloid. It's structurally related to saxitoxin, but with some differences. ZTX has a guanidine core similar to saxitoxin. It contains an isoxazolidine ring, a sulfonate group and a N-hydroxycarbamate group.
Mechanism of action
ZTX is an extremely potent sodium channel blocker. It has been shown to block the voltage-gated sodium channels at picomolar concentrations. It is about 580 times more potent than saxitoxin.
Toxicity
ZTX is an extremely potent neurotoxin. The LD50 of ZTX in mice is 11 μg/kg.